Xavier Navarro Acebes

Xavier  Navarro Acebes

 

Xavier Navarro Acebes

Teléfono:
+34 935 811 966

Email:
xavier.navarro@uab.cat

Dirección:

Department of Cellular Biology, Physiology and Immunology
Institut de Neurociències
Faculty of Medicine (room M4-118)
Universitat Autònoma de Barcelona (UAB)
Bellaterra Campus 08193-Cerdanyola del Vallés


Xavier Navarro received the MD degree in 1978 and the PhD degree in 1985 from the Unversitat Autonoma de Barcelona (UAB). He completed his speciality training in Neurology at the University of Barcelona, and in Neurophysiology at the University of Minnesota. He was Assistant Porfessor of the Department of Neurology of the University of Minnesota (1986-1988). He returned in 1988 to the UAB as Associate Professor in the Department of Cell Biology and Physiology, where he is currently full Professor of Physiology since 1999. He has been a founder of the Institute of Neurosciences of the UAB, and the director of the Department (2010-2016).  He also serves as scientific advisor of the Institut Guttmann of Neurorehabilitation.
Since 1989 he is coordinating the research Group of Neuroplasticity and Regeneration. His research interests are focused on axonal regeneration, functional restitution after nerve injuries, cell and molecular therapies for spinal cord injuries, neuroprostheses, peripheral neuropathies, neuropathic pain and motoneuron diseases. He has published more than 350 papers in refereed journals and books in these areas of the neurosciences, with an H-index of 55, and directed 26 PhD theses. He has been member of the editorial boards of: Restorative Neurology and Neuroscience, Journal of the Peripheral Nervous System, Muscle and Nerve, Frontiers in Neuroengineering, Neural Plasticity. He has received awards “Ciutat de Barcelona” in 1995, “Josep Trueta” in 2000, ASPAYM in 2009 for his scientific research activities.
 

Dr. Xavier Navarro coordinates the research group in Neuroregeneration and plasticity:

 

 

Group members:

 

Principal Investigators:

Xavier Navarro

Esther Udina

Rubèn López

Caty Casas

Jordi Bruna

Roser Velasco

Jorge Juan Vilches

Ignacio Delgado

Guillermo García

 

Postdoctoral researchers:

Joaquim Hernández

Jaume del Valle

Mireia Herrando

Clara Penas

David Romeo

 

Pre-doctoral researchers:

Anna Martínez

Natàlia de la

Clara López

Jesus Amo

Guillem Mòdol

Alba Sánchez

Maria Puigdomènech

Núria Gaja

Aina Calls

Olaia Baylo

Maria Rodríguez

Tatiana Leiva

Sara Marmolejo

 

Technicians:

Mònica Espejo

Jèsica Jaramillo

Israel Blasco

Neus Solanes

 

Collaborators:

Joaquín Forés Viñeta, Consultor Senior, Hospital Clínic i Provincial de Barcelona

Jordi Badia Casahuga

Miguel Angel Rubio, Metge adjunt, Hospital del Mar

 

  

RESEARCH INTERESTS

 

The Group of Neuroplasticity and Regeneration of the UAB is a multidisciplinary research group working on repair, regeneration and functional recovery after peripheral nerve and spinal cord lesions and in neurodegenerative diseases.

 

 

RESEARCH LINES

 

- Cellular and molecular mechanisms involved in degeneration of motoneurons in experimental models. Neuroprotective strategies based on gene and pharmacological therapy.

- Cell therapy by transplantation of mesenchymal stem cells and olfactory glia for the repair of spinal cord injuries and motoneuron degenerative diseases.

- Etiopathogenic role of lipid mediators and modulators of the neuroinflammatory response in neurodegeneration induced by central nervous system lesions.

- Activity-dependent therapies for enhancing axonal regeneration and functional recovery after peripheral nerve lesions.

- Physiopathological mechanisms in neuropathic pain induced by nerve and spinal cord lesions.

- Etiopathogenic mechanisms and potential neuroprotective treatments in peripheral neuropathies induced by diabetes and by antitumoral agents.

- Design and evaluation of neural interfaces for the development of neuroprostheses applied to neurorehabilitation.

- Neuromodulation for functional recovery in spinal cord injuries and degenerative processes.  

See all Xavier Navarro  publications at PubMed.

SELECTED REPRESENTATIVE PUBLICATIONS

  • Navarro X, Kennedy WR, Sutherland DER. Long-term effects of pancreatic transplantation on diabetic neuropathy. Ann Neurol 1997, 42:727-736.
  • Navarro X, Valero A, Gudiño G, Forés J, Rodríguez FJ, Verdú E, Pascual R, Cuadras J, Nieto-Sampedro M. Ensheathing glia transplants promote dorsal root regeneration and spinal reflex restitution after multiple lumbar rhizotomy. Ann Neurol 1999, 45:207-215.
  • Rodríguez FJ, Verdú E, Ceballos D, Navarro X. Neural guides seeded with autologous Schwann cells improve nerve regeneration. Exp Neurol 2000, 161:571-584.
  • Verdú E, García-Alías G, Forés J, López-Vales R, Navarro X. Olfactory ensheathing cells transplanted in lesioned spinal cord prevent loss of spinal cord parenchyma and promote functional recovery. Glia 2003, 42:275-286.
  • Udina E, Ceballos D, Gold BG, Navarro X. FK506 enhances reinnervation by regeneration and by collateral sprouting of nerve fibers. Exp Neurol 2003, 183:220-231.
  • Udina E, Rodríguez FJ, Verdú E, Espejo M, Gold BG, Navarro X. FK506 enhances regeneration of axons across long peripheral nerve gaps repaired with collagen guides seeded with allogeneic Schwann cells. Glia 2004, 47:120-129.
  • Lago N, Ceballos D, Rodríguez FJ, Stieglitz T, Navarro X. Long term assessment of axonal regeneration through polyimide regenerative electrodes to interface the peripheral nerve. Biomaterials 2005, 26:2021-2031.
  • Navarro X, Krueger T, Lago N, Micera S, Stieglitz T, Dario P. A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems. J Peripher Nerv System 2005, 10:229-258.
  • López-Vales R, Forés J, Verdú E, Navarro X. Acute and delayed transplantation of olfactory ensheathing cells promote partial recovery after complete transection of the spinal cord. Neurobiol Dis 2006, 21: 57-68.
  • Navarro X, Vivó M, Valero-Cabré A. Neural plasticity after peripheral nerve injury and regeneration. Progr Neurobiol 2007, 82:163-201.
  • Penas C, Casas C, Robert I, Forés J, Navarro X. Cytoskeletal and activity-related changes in spinal motoneurons after root avulsion. J Neurotrauma 2009, 26:763-779.
  • Soler D, Kumru H, Pelayo R, Vidal J, Tormos JM, Fregni F, Navarro X, Pascual-Leone A. Effectiveness of transcranial direct current stimulation and visual illusion on neuropathic pain in spinal cord injury. Brain 2010, 133:2565-2577.
  • Allodi I, Udina E, Navarro X. Specificity of peripheral nerve regeneration: interactions at the axon level. Progr Neurobiol 2012, 98:16-37.
  • Torres-Espín A, Corona-Quintanilla DL, Forés J, Allodi I, González F, Udina E, Navarro X. Neuroprotection and axonal regeneration after lumbar ventral root avulsion by reimplantation and mesenchymal stem cells transplant combined therapy. Neurotherapeutics 2013, 10:354-368.
  • Mancuso R, del Valle J, Mòdol L, Martinez A, Granado-Serrano AB, Ramirez-Núñez O, Pallás M, Portero-Otin M, Osta R, Navarro X. Resveratrol improves motoneuron function and extends survival in SOD1G93A ALS mice. Neurotherapeutics 2014, 11:419-432.
  • Mancuso R, Navarro X. Amyotrophic lateral sclerosis: current perspectives from basic research to the clinic. Progr Neurobiol 2015, 133:1-26.
  • Mancuso R, Martínez-Muriana A, Leiva T, Gregorio D, Ariza L, Morell M, Esteban-Pérez J, García-Redondo A, Calvo AC, Atencia-Cibreiro G, Corfas G, Osta R, Bosch A, Navarro X. Neuregulin-1 promotes functional improvement by enhancing collateral sprouting in SOD1G93A ALS mice and after partial muscle denervation. Neurobiol Dis 2016, 95:168-178.
     
Instituto de Neurociencias
Tel: 93 581 3861 / Fax: +34 93 581 3327

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