Juan Hidalgo Pareja

Juan  Hidalgo Pareja



Juan Hidalgo Pareja

+34 935 812 037



Department of Cellular Biology, Physiology and Immunology
Institut de Neurociències
Faculty of Biosciences (room C2-033)
Universitat Autònoma de Barcelona (UAB)
Bellaterra Campus 08193-Cerdanyola del Vallés

Juan Hidalgo finished his Biology Degree in 1982 and defended his PhD thesis, supervised by Drs. Antonio Armario and Rosa Flos, in 1986 at the UAB. He has conducted studies and research at the UAB and has collaborated with different laboratories worldwide. He is an ordinary member of the Spanish Society of Neuroscience (SENC) and Spanish Society of Physiology. He coordinates a group of experimental research studying neuroinflammation in animal models.

Dr. Hidalgo is the coordinator of the research group Neuroinflammation and Oxidative Stress, in which his own laboratory is included:




Laboratory members:

Gemma Comes Orpinell
Mercè Giralt Carbonell
Amalia Molinero Egea
Olaya Fernández Gayol

Former lab members:
María Erta Cabañate
Beatriz Ferrer Villahoz
Javier Carrasco Trancoso




The fundamental objectives  of the Group are centred in the study of the basic mechanisms underlying neuroinflammation and oxidative stress, with a particular emphasis in the role of the cytokine interleukin 6 (IL-6) in animal models of neurodegenerative diseases such as Alzheimer disease and multiple sclerosis (MS) and in animal models of traumatic brain lesion.


1) Traumatic brain injury (TBI) is one of the main causes of death and disability, especially among young people. Cytokines such as IL-6 and TNFα are involved in the response of the CNS to brain injury; by means of conditional KO mice produced in our laboratory, we will analyze the importance of the cellular sources of IL-6 in a model of TBI. Moreover, by using conditional KO mice for the receptor of IL-6 we will also determine the importance of the specific cellular response to IL-6. At this time we are focusing on the main glial cell, the astrocyte.


2) Alzheimer disease models. One of the animal models of Alzheimer disease more often used in the APP2576 mouse; the importance of oxidative stress in this model is being evaluated by analyzing the phenotype of the APP mice crossed with mice with altered expression of the antioxidant protein metallothionein.


3) Animal models of Multiple Sclerosis (MS). There are a number of models of MS, being Experimental Autoimmune Encephalitis (EAE) one of the more studied. We will evaluate the importance of the cytokine IL-6 in this model by using transgenic mice (see 1).


4) Exercise and obesity. The importance of IL-6 in the response to exercise and diet-induced obesity.







  • Manso Y, Comes G, López-Ramos JC, Belfiore M, Molinero A, Giralt M, Carrasco J, Adlard PA, Bush AI, Delgado-García JM, Hidalgo J. Overexpression of metallothionein-1 modulates the phenotype of the Tg2576 mouse model of Alzheimer’s disease. J. Alzheimer’s Dis. 51 (2016) 81-95.
  • Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 18 (2017) 74-85.
  • Gubernatorova EO, Gorshkova EA, Namakanova OA, Zvartsev RV, Hidalgo J, Drutskaya MS, Tumanov AV, Sergei A. Nedospasov SA. Non-redundant functions of IL-6 produced by macrophages and dendritic cells in allergic airway inflammation. Front. Immunol. 9 (2018) 2718.
  • Comes G, Fernandez-Gayol O, Molinero A, Giralt M, Capdevila M, Atrian S, Hidalgo J. Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in the animal model of multiple sclerosis, EAE. Metallomics 
  • Different responses to a high-fat diet in IL-6 conditional knock-out mice driven by constitutive GFAP-Cre and Synapsin 1-Cre expression. Neuroendocrinology 

See all publications

Instituto de Neurociencias


Tel: 93 581 3861
Fax: +34 93 581 3327


Tel: 93 581 33 27

Facultad de Medicina. Edificio M-1
Calle de la Vinya - Campus de la UAB · 08193
Bellaterra (Cerdanyola del Vallès) · Barcelona