Institut de Neurociències (INc) - UAB Barcelona

3D biopsies to better understand brain tumors

3D biopsies to better understand brain tumors

Researchers of the Neuroimmunity lab obtained a highly accurate recreation of human glioblastoma’s features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. Read the article

19/02/2021

This new analysis of 3D images and quantitative data “will help to appreciate from within how the tumor is built in its full dimensionality, and to identify where different cell types are located”, explains George Paul Cribaro, first author of the study. “It provides more complete information than the usual 2D analyses performed for neuropathological diagnosis”

With this new approach, authors show the alterations in tumor blood vessels do not hinder the entrance of lymphocytes T (potential defense against tumoral cells), which is relevant for the design and use of immunotherapies targeting malignant cells.

Moreover, the images allow the tumor to be differentiated into two areas, the tumor tissue properly speaking, and the stroma, which gives support to the tumor, in which there are different immunological microenvironments. “Immune cells like microglia and macrophages are seen in both areas, but they are shaped by different subpopulations. This local and populational differentiation could be an important factor that may help diagnosis and aid in the search for new therapeutic targets”, indicates Carlos Barcia, coordinator of the work.

The work provides a set of resource images that will facilitate the understanding of the complexity of this tumor, showing some aspects to be considered when designing new therapeutic approaches. Read the article



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The H2020 project QSPainRelief awarded by the European Commission

The H2020 project QSPainRelief awarded by the European Commission

The QSPainRelief project "Effective combinational treatment of chronic pain in individual patients by an innovative quantitative systems pharmacology pain relief approach", which includes the participation of Dr. Jesús Giraldo’s team (Institute for Neurosciences and Biostatistics Unit of the School of Medicine), has been funded from the European Commission.

This  project will attempt to solve a crucial problem since about 20% of Europeans suffer from chronic pain and current therapies are not effective in many cases. Around 60% of patients do not reach enough relief from traditional painkillers, which in turn can lead to several adverse effects.

The QSPainRelief project addresses the problem of chronic pain by identifying new drug combinations that are expected to increase analgesic efficacy while reducing side effects. To do this, quantitative systems pharmacology and computational modeling will be used. The best combinations will be validated in animal models and clinical studies.

The QSPainRelief project will receive more than € 6 million in funding for 5 years through the H2020 program. The project is a collaboration between 9 research institutions from 6 different countries, including the UAB, starting January 1, 2020.

A new model of the worm C. elegans to progress in the study of a rare disease of the nervous system

A new model of the worm C. elegans to progress in the study of a rare disease of the nervous system

In a research co-directed by Dr Esther Dalfó, researcher at the Institute and professor at UVic-UCC, a model of chromosome X-linked adrenoleukodystrophy (x-ALD) has been indentified in the earthworm C. elegans.

The model will permit to accelerate and reduce the price of the research, which is studying the mechanisms and the possible pharmacological targets for the neuronal alterations of this disease.

The earliest results of studies with this organism point to glial cells as a man responsible for the neurological damage caused by the disease.

The work was done at the IDIBELL Neurometabolic Diseases group, with international collaborations, and has been published in the Free Radical Biology and Medicine journal.

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