Research Group in Demyelinating Autoimmune Diseases (NeuroGene)

 

 

 

Coordinator: Dr. Miguel Chillón

 

LABORATORIES:

- Dr. Assumpció Bosch

- Dr. Miguel Chillón

- Dr. Ester Fernández

- Dr. Lydia Giménez-Llort

 

The research activity of our group is aimed at defining, characterizing and applying gene therapy strategies for neurodegenerative and demyelinating diseases that affect both the central nervous system and the peripheral nervous system. To achieve this, our 3 main strategic objectives are:

1.- Development of gene therapy strategies for neurodegenerative diseases whether of genetic origin such as mucopolysaccharidosis, or acquired, as Alzheimer's Disease

2.- Development of gene therapy strategies for autoimmune demyelinating diseases such as: (a) Multiple Sclerosis (MS), and (b) peripheral diabetic neuropathy (PND), studing them integrally from different angles, as by analyzing the autoimmune process (role of TLRs, deregulation of Th17 pathway, etc.), or the molecular mechanisms involved in the demyelination process.

3.- Development of gene therapy vectors and optimization of the production / purification processes.

 

 

Active projects:

 

- 2016 LLAV 00033: Validation of the capacity of sKL in bloodstream to cross BBB and its therapeutic use in neurodegenerative and dyemilinating diseases. Ajuts Llavor per a projectes innovadors amb potencial d'incorporació al sector productiu (IP: Miguel Chillón)

 

- Arrest-AD: 3- O-Sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration. European Union's Horizon 2020 FET OPEN Research and Innovation program (IP: L. Gimenez-Llort)

 

- Teràpia gènica combinada per corregir l’estrès oxidatiu i de reticle en neuropatia diabètica de tipus 2. Marato TV3. (IP: M. Chillon)

 

- Advancecat: Acceleradora pel desenvolupament de terapies avançades a Catalunya. Comunitats RIS3CAT. (Projecte coordinat. IP_UAB: M. Chillon)

 

- Estudio molecular y tratamiento de la Mucopolisacaridosis tipo VII. ISC-III #01271. (PI: A. Bosch)

 

- Red española de adenovirus: desde la Biología básica a la Nanobiomedicina. MICINN: Acciones de dinamización "Redes de Excelencia. (Projecte coordinat. IP_UAB: M. Chillon)

 

- Estudio del papel de la isoforma soluble de alpha-Klotho en el inicio y progresión de déficits cognitivos: marcador de diagnóstico precoz, y molécula diana con potencial terapéutico. ISC-III #01270. (PI: M. Chillon)

 

- Unitat Producció de Vectors (UPV). TECNIO (ACCIO). (PI: M. Chillon)

 

- Optimización y desarrollo de un agente terapéutico basado en ácidos nucleicos para el tratamiento de la enfermedad de Huntington. RETOS-Colaboracion. MINECO. (Projecte coordinat. IP_UAB: A.Bosch)

 

- P115/01255; Mecanismos convergentes entre autofagia y función axonal e influencia metabólica en la regulación de las enfermedades neurodegenerativas (Confinanciado por la Unión Europea y el Instituto de Salud Carlos III)

 

 

 

 

Featured publications:

 

- Massó A, Sánchez A, Bosch A, Giménez-Llort L, Chillón M. Secreted αKlotho isoform protects against age-dependent memory deficits. (2017). Mol Psychiatry. Oct 31. doi: 10.1038/mp.2017.211. [Epub ahead of print]

- Marta Miralles, Herena Eixarch, Marcos Tejero, Carme Costa, Keiji Hirota, A. Raul Castaño, Meritxell Puig, Gitta Stockinger, Xavier Montalban, Assumpció Bosch, Carmen Espejo, Miguel Chillon. Clinical and Histopathological Amelioration of Experimental Autoimmune Encephalomyelitis by AAV Vectors Expressing a Soluble Interleukin-23 Receptor. (2017). Neurotherapeutics Oct;14(4):1095-1106.

- Burgueño JF, Barba A, Eyre E, Romero C, Neunlist M, Fernández E. TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide. (2016). J Neuroinflammation. 13(1):187-201

- R. Thwayte, G. Pages, M. Chillon, and A. Bosch. AAVrh.10 immunogenicity in mice and humans. relevance of antibody cross-reactivity in human gene therapy. (2015). Gene Therapy; 22: 196-201.

- Torres-Lista V, Parrado-Fernández C, Alvarez-Montón I, Frontiñán-Rubio J, Durán-Prado M, Peinado JR, Johansson B, Alcaín FJ, Giménez-Llort L. Neophobia, NQO1 and SIRT1 as premorbid and prodromal indicators of AD in 3xTg-AD mice. (2014). Behav Brain Res. 271:140-6.

 

 

Funding:

 

  

 

Ref: SGR2017-1468