Neuroinflammation and Oxidative Stress




Coordinador: Dr. Juan Hidalgo Pareja


- Dr. Juan Hidalgo Pareja



Our objective is to understand the role of IL-6 cytokine in the brain, studying IL-6-secrating cells and their receptors. We explore the roles of IL-6 in astrocytes, neurones and microglia using mice models; both in physiologic normal conditions (analysing their behaviour, body weight and growth control) and during neuroinflammatory processes, particularly in Multiple Esclorosis models (Autoimmune Experimental Encephalitis) and Alzheimer Disease. 



Projectes actius:


1) RTC-2016-4955-1; Regulación epigenética de la respuesta inflamatoria.


2) SAF2014-56546-R; Generación de nuevos ratones transgénicos y su aplicabilidad en modelos de enfermedades neurodegenerativas con un claro componente neuroinflamatorio.


3) 273/U/2014; Role of IL-6 trans-signaling in a mouse model of Alzheimer’s disease.





Publicacions seleccionades:


· Giralt M, Ramos R, Quintana A, Ferrer B, Erta M, Castro-Freire M, Comes G, Sanz E, Unzeta M, Pifarré P, García A, Campbell IL, Hidalgo J. Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6. Glia 61 (2013) 587-600.


· Campbell IL, Erta M, Lim SL, Frausto R, May U, Rose-John S, Scheller J, Hidalgo J. Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain. J. Neurosci. 34 (2014) 2503-2513.


· Erta M, Giralt M, Esposito FL, Fernandez-Gayol O, Hidalgo J. Astrocytic IL-6 mediates locomotor activity, exploration, anxiety, learning and social behavior. Horm. Behav. 73(2015) 64-74.


· MansoY, Comes G, López-Ramos JC, Belfiore M, Molinero A, Giralt M, Carrasco J, Adlard PA, Bush AI, Delgado-García JM, Hidalgo J. Overexpression of metallothionein-1 modulates the phenotype of the Tg2576 mouse model of Alzheimer’s disease. J. Alzheimer’s Dis.51 (2016) 81-95.


· Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol. 18 (2017) 74-85.



Fonts de finançament:



Ref: SGR 2017-0104