Miguel Chillón Rodríguez

Miguel  Chillón Rodríguez

 

 

Miguel Chillón Rodríguez

Academic Staff

Phone:
+34 935 814 199

Email:
miguel.chillon@uab.cat

Adress:

Department of Biochemistry and Molecular Biology
Institut de Neurociències
CBATEG (room H-504)
Universitat Autònoma de Barcelona (UAB)
Bellaterra Campus 08193-Cerdanyola del Vallés

Area

Thesis number in address


Born in Barcelona in 1966. PhD in Genetics at Hospital Duran i Reynals and Universitat de Barcelona, 1994. National Award in Human Genetics by the Spanish Association of Human Genetics in 1995. HHMI postdoctoral fellow on Gene Therapy for Cystic Fibrosis, at the Internal Medicine Dept, University of Iowa, USA (1994-1997). EMBO fellow in Genethon III (Evry, France) (1997-1999) on Development of viral vectors for Gene Therapy. Postdoctoral fellow on Gene Therapy (2000-2001) at the Universitat Autònoma de Barcelona (UAB). ICREA Research Professor at the UAB since 2001. Scientific Responsible of the Vector Production Unit, a technological platform to produce viral vectors, since 2004. Assistant Professor of the Biochemistry and Molecular Biology Dept. at the UAB since 2005. Member of the Biosafety Committee of the UAB since 2006. Co-founder of NanoTherapix, a spin-off company in biotechnology, in 2009. He has published more than 70 papers and generated 7 patents in viral vectors.

Dr. Miguel Chillón is the coordinator of the NeuroGene research group and is also leading his own laboratory:
 
 
Laboratory members:
Àngel Edo Salvador
Susana Miravet Delgado
Roberto Notario Manzano
María Ontiveros González
Jose Antonio Piedra Bueno
Meritxell Puig Ferrer
Marcos Tejero Ambrosio
 
 
RESEARCH LINES
 
1) Molecular mechanisms involved in memory formation: Study of altered signaling pathways in CNS in aging and in Alzheimer's Disease
2) Gene Therapy Strategies for Esclerosis Multiple, an autoimmune disease affecting the nervous system
3) Generation and development of more selective and less immunogenic viral vectors
 

FUNDING
 
ISC-III (#PI15-01270); EU (FP7-286071-BRAINVECTORS), AGAUR, Fundación Genzyme en Esclerosis Múltiple, Agreements with private biotech-companies.
 

PATENTS
 
Método de producción de vectores adenovirus para terapia génica y secuencias de ADN útiles para ello. WO 2007/125146. Fecha de prioridad: 28/04/06
Transposón Hsmar2 y su uso en la generación de vectores útiles en terapia génica  somática. P200602688. Fecha de prioridad: 18/10/06
Methods and reagents for efficient and targeted gene transfer to monocytes and macrophages. WO 2010/125115.; EP09159001.8; Fecha de prioridad: 24/12/10
Antibodies against mammal secreted Klotho protein. EP15160093.9. Fecha de prioridad: 20/03/15
Secreted splicing variant of mammal Klotho as a medicament for cognition and behaviour impairments. EP15195470.8. Fecha de prioridad : 19/11/15
  • Massó A, Sánchez A, Bosch A, Giménez-Llort L, Chillón M. Secreted αKlotho isoform protects against age-dependent memory deficits. Mol Psychiatry. 2018 Sep;23(9):1-11.

  • A. Massó, A. Sánchez, L. Giménez-Llort J.M. Lizcano M. Cañete, B. García, V. Torres-Lista, M. Puig, A. Bosch, M. Chillon. Secreted and transmembrane alfa-klotho isoforms have different spatio-temporal profiles in brain during  aging and Alzheimer's disease progression. Plos One: 10(11):e0143623. 2015
  • A. Ortega-Esteban, G. N. Condezo, A. J. Pérez-Berná, M. Chillon, S. J. Flint, D. Reguera, C. San Martín, P. J. de Pablo. Mechanics of viral chromatin reveals the pressurization of human adenovirus. ACS Nano: 9(11):10826-33. 2015
  • G. N. Condezo, R. Marabini, S. Ayora, J. M. Carazo, M. Chillon, C. San Martín. Structures of adenovirus incomplete particles clarify capsid architecture and show maturation hanges of packaging protein L1 52/55k. Journal of Virology: 89(18):9653-64. 2015
  • J. Piedra, M. Ontiveros, S. Miravet, C. Penalva, M. Monfar, M. Chillon. Development of a rapid, robust and universal picogreen-based method to titer adeno-associated vectors. Human Gene Therapy Methods: Feb;26(1):35-42. 2015
  • R. Thwayte, G. Pages, M. Chillon, and A. Bosch. AAVrh.10 immunogenicity in mice and humans. relevance of antibody cross-reactivity in human gene therapy. Gene Therapy: 22: 196-201. 2015
  • L. Ariza, G. Pagès, B. García-Lareu, X. Navarro, M. Chillon, J. Ruberte, P.Otaegui, and A. Bosch. Experimental diabetes in neonatal mice induces early peripheral sensorimotor neuropathy. Neuroscience: 274:250-9. 2014
  • L. Ariza, L. Giménez-Llort, A. Cubizolle, G. Pagès, B. García-Lareu, N. Serratrice, D. Cots, M. Chillon, E. Kremer and A. Bosch.CNS delivery of helper-dependent canine adenovirus corrects neuropathology and behavior in Mucopolysaccharidosis type VII mice. Human Gene Therapy: 25(3):199-211. 2014
  • J. Homs, G. Pages, L. Ariza, C. Casas, M. Chillon, X. Navarro, A. Bosch. Intrathecal Administration of IGF-I by AAVrh10 Improves Sensory and Motor Deficits in a Mouse Model of Diabetic Neuropathy. Molecular Therapy-Methods & Clinical Development: Jan 15;1:7. 2014
  • M. Chillon and A. Bosch (Editors). Adenovirus: Methods and Protocols. Methods Molecular Biology, Third Edition, New York, USA. Humana Press. Volumen:1089. ISBN:978-1-62703-678-8.2014
  • M. Miralles, M. Garcia, M. Tejero, A. Bosch, M. Chillon. Production of chimeric adenovirus. Methods Molecular Biology. Adenovirus: Methods and Protocols, Third Edition, New York, USA. Humana Press: 1089:231-43. 2014
  • Miravet S, Ontiveros M, Piedra J, Penalva C, Monfar M, M. Chillon. Construction, production, and purification of recombinant adenovirus vectors. Methods Molecular Biology. Adenovirus: Methods and Protocols, Third Edition, New York, USA. Humana Press:1089:159-73.2014
  • D. Cots, A. Bosch, M. Chillon. Helper-dependent adenovirus vectors: Progress and future prospects. Current Gene Therapy: 15:3; 370-381. 2013
  • E. Laborda, C. Puig-Saus, M. Cascalló, M. Chillon and R. Alemany.Adeno-associated virus enhances wild type and oncolytic adenovirus spread. Human Gene Therapy Methods: 24:372-380. 2013
  • E. Gil, A. Bosch, D. Lampe, J. M. Lizcano, J. C. Perales, O. Danos, M. Chillon. Functional characterization of the human mariner transposase Hsmar2. Plos One: 8(9): e73227:1-12. 2013
  • Stefania Piersanti, Letizia Astrologo, Valerio Licursi, Rossella Costa, Enrica Roncaglia, Aurelie Gennetier, Sandy Ibanes, M. Chillon, Rodolfo Negri, Enrico Tagliafico, Eric J Kremer. Differentiated neuroprogenitor cells incubated with human or canine adenovirus, or lentiviral vectors have distinct transcriptome profiles. Plos One: 26;8(7):e69808: 1-14. 2013
  • E. Rodríguez, C. Romero, A. Río, M. Miralles, A. Raventós, L. Planells, J. F. Burgueño, H. Hamada, J. C. Perales, A. Bosch, M. A. Gassull, E. Fernández,M. Chillon. Short fiber protein of Ad40 confers enteric tropism and protection against acidic gastrointestinal conditions. Human Gene Therapy Methods: 24(4): 195-204. 2013

See all M.Chillon publications at PubMed

Institut de Neurociències
Tel: 93 581 3861 / Fax: +34 93 581 3327

Facultat de Medicina. Edifici M-1
Avinguda de Can Domènech - Campus de la UAB · 08193
Bellaterra (Cerdanyola del Vallès) · Barcelona