Lydia Giménez Llort

Lydia Giménez Llort

Lydia Giménez Llort

Academic Staff

Phone:
+34 935 812 378

Email:
lidia.gimenez@uab.cat

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Associate Professor in Psychiatry and Research in Behavioral Neuroscience and Biological Psychiatry in the Department of Psychiatry and Forensic Medicine, Faculty of Medicine and the Institute of Neurosciences of the Universitat Autònoma de Barcelona.

My career reflects the multidisciplinary curriculum that has characterized my academic and experimental profile since my degree in Biology (1984-1989). After the Master on the functional role of LPL, lipase protein in rat liver in the Dept Biochemistry and Molecular Biology at the UAB (1991 UB) I became interested in the knowledge of the brain and moved to CSIC, Spanish Research Council for my PhD in Dept. Neurochemistry (Supervision: E.Martinez) with co-direction from the Pharmacology and Toxicology, to study the behavioral effects of NMDA system and its interactions with dopamine systems, adenosine and polyamines (CSIC and UB, 1996). It is during this predoctoral stage that was forged my core curriculum feature: studying behavior in rodents (rats and mice), from an ethological and experimental view, thanks to animal models for neurological diseases (epilepsy, Parkinson's, schizophrenia) achieved by administration and systemic drug interactions. Further adds methodological innovation of image analysis systems for measuring behavior. This page is secured during my postdoctoral stay at the Karolinska Institute in Sweden (1996-1998), where extensive experimental approaches with local administration, microdialysis and mutant animals models, the emergence of the knockout transgenic animals and 90’s, under the supervision Sven Ove Ogren (AstraZenca and KI) and working together with five members of the Nobel Committee, to characterize their new mutant mice were generated in their laboratories. In addition, during the first months of my stay (April-May 1996) I developed a new method of 'gait analysis' that helped to show the central coordination of paraplegic rats following a new strategy to repair (Chen et al., Doctoral thesis, 2006). Reinstated to Spain by Generalitat de Catalunya and the MEC reincorporation contracts (1999-2001), I got 1/50 first promotion of Ramón y Cajal Contracts in the Area of Medicine (2002-2006) and Outstanding Career Researcher I3 (2006-2009) immediately before the Associate Professorship in Psychiatry in 2007. Since then I have continued the behavioral characterization of animal models for neurological and psychiatric diseases, and established the Spanish colony of mice 3xTg-AD at the UAB through Material Transfer Agreement (2004, 2007) with Dr. FM LaFerla (UCI, USA). Since 2004, the animals I breed have been the experimental subjects of 18 doctoral theses and 25 projects of national and international research, to highlight the European project FP7 MEMOSAD and European action COST-Action TD1005 'pain and cognitive damage' where I am the Spanish representative. I’m also member of SGR1354 2014, RETICEF (RD06 / 0013/0003, RD12 / 0043/0018), UCM-CM ENEROINN 910 379, CORE Salut Mental de Catalunya, and founder of 4the5 Network. The translational approach is done through cooperation agreements with Karolinska Institute, Sweden (Bjorn Johansson IP),  Hospital Sagrat Cor Martorell, Barcelona (IP: Manel Sanchez). , UVAMID Hospital Santa Katerina, Salt, Girona (IP: secundi Lopez-Pousa).

Dr. Lydia Giménez is a Principal Investigator a the NeuroGene research group and leads her own laboratory:

Laboratory members:
Mikel Santana Santana
Lidia Castillo Mariqueo
Aida Muntsant Soria
Daniela Marin Pardo


STRATEGIC OBJECTIVES

Modeling and characterizing behavioral and neuroinmunoendocrine phenotypes related to the process of aging or those characteristic of neurodegenerative or neurological disorders is a challenge but it is relevant in order to provide research tools to study the mechanisms underlying the pathophysiological events and to assess the potential of preventive and therapeutical strategies. Our research is focused on behavioral neuroscience (behavioral screening, behavioral pharmacology and non-pharmacological approaches) with a 'bed-to-bench' and 'bench-to-bed' translational view. We are also interested in the social and intergenerational relationships in the human being and their impact on the well-being of the elderly. An issue that we also try to address from basic research. We are members of SGR1354 2014 (Coordinador: Miguel Chillón), RETICEF (RD06/0013/0003), UCM-CM ENEROINN 910379 (UCM, PI: Mónica De la Fuente), Network 4the5. (CEO:Lydia Giménez-Llort), Neurogenet Consortium (IGTP, CSIC, UAB, Coordinador: Antonio Matillas). Lydia Gimenez Llort is the representative for Spain at the European Cooperation in the Field of Scientific and Technical Research COST-action TD1005 ‘Pain Assessmment in Patients with Impaired Cognition, especially Dementia’ The translational approach is achieved thanks to research agreements with Karolinska Hospitals of Karolinska Institute, Stockholm, Sweden (PI: Björn Johansson), UVAMID Hospital Santa Katerina, Salt, Girona (PI: Secundí López-Pousa), Neurogenet Consortium (IGTP, CSIC, UAB; Coordinator: Antoni Matilla) and Hospital Sagrat Cor de Martorell (PI: Manel Sánchez).
 

MAIN RESEARCH LINES
 
1. Establisment of the colonies of 3xTg-AD and wild-type mice. Behavioral characterization of cognitive and BPSD-like symptoms in animal models of aging and dementia.
2. Behavioral assessment of non-pharmacological (handling, enrichment, exercice)   preventive and therapeutical strategies in animal models of aging and neurodegenerative disorders, with special focus in our colonies of 3xTg-AD mice.
3. Behavioral pharmacology of NMDA-DA-Adenosine interactions in animal models for psychitaruc and neurologic disorders.


Spanish colony of 3xTgAD-mice
Lydia Giménez-Llort established the Spanish colonies of triple-transgenic 3xTg-AD mice and their wild-type strain thanks to MTAs (2004; 2007) with Dr. F.M. LaFerla (University of California Irvine, USA). The triple-transgenic 3xTg-AD mice (Oddo et al, 2003, Neuron, 39, 409-421) harboring PS1M146V, APPSwe and tauP301L transgenes progressively develop βA plaques and neurofibrillary tangles with a temporal- and regional-specific profile that closely mimics their development in the human AD brain. Synaptic and cognitive disfunction are manifested in an age and gender-dependent manner, but before plaque and tangle pathology. Nowadays, this model is one of the most promising tools to study the mechanisms of action of the pathophysiological contribution of intracellular βA in AD, and try to determine how extensive plaque, as well as tangle pathologies may contribute to late-stage cognitive deficits, assess second generation therapeutical strategies and to which extent preventive approaches are able to improve both behavioral and pathological phenotypes.

 
ONGOING PROJECTS
  • 3-O-sulfated heparan sulfate translocation in altered membrane biology: A newstrategy for early population screening and halting Alzheimer’s neurodegeneration. FETOPEN-01-2016-2017 - FET-Open research and innovation actions

SELECTED PUBLICATIONS

•  Johansson, B.,  Halldner, L., Dunwiddie, T.V., Masino, S.A., Poelchen, W., Giménez-Llort, L., Escorihuela, R.M., Fernández-Teruel, A., Wiesenfeld-Hallin, Z., Xu X.-J., Hårdemark, A., Betsholtz, Ch., Herlenius, E., Fredholm, B.
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor.
Proc. Nat. Acad. Sciences98 (16), 9407-9412.2001

•  Giménez-Llort, L.*, Blázquez, G., Cañete, T., Johansson, B., Oddo,S., Tobeña,A, LaFerla, F.M., Fernández-Teruel, A.
Modeling behavioral and neuronal symptoms of Alzheimer disease in mice: a role for intraneuronal  amyloid.
Neurosci Biobehav Rev. 31(1):125-47,2007

•  España J, Giménez-Llort L, Valero J, Miñano A, Rábano A, Rodriguez-Alvarez J, LaFerla FM, Saura CA
Intraneuronal beta-Amyloid Accumulation in the Amygdala Enhances Fear and Anxiety in Alzheimer's Disease Transgenic Mice.
Biol Psychiatry.67(6): 513-521, 2010

•  Solé-Domènech S, Sjövall P, Vukojevi? V, Fernando R, Codita A, Salve S, Bogdanovi? N, Mohammed AH, Hammarström P, Nilsson KP, Laferla FM, Jacob S, Berggren PO, Giménez-Llort L, Schalling M, Terenius L, Johansson B.
Localization of cholesterol, amyloid and glia in Alzheimer's disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging.
Acta Neuropathol. 125(1):145-57. 2013

•  Giménez-Llort L, Torres-Lista V, De la Fuente M.
Crosstalk between the nervous and the immune system during the prodromal stages of Alzheimer’s disease. In: Special Issue “Crosstalk between the nervous and the immune system in health and in sicknes”. Curr Pharm Des. 2014;20(29):4723-32

See more L. Gimenez-Llort in PubMed.

Institut de Neurociències
Tel: 93 581 3861 / Fax: +34 93 581 3327

Facultat de Medicina. Edifici M-1
Avinguda de Can Domènech - Campus de la UAB · 08193
Bellaterra (Cerdanyola del Vallès) · Barcelona