José Rodríguez Alvarez

José  Rodríguez Alvarez


José Rodríguez Alvarez

Academic Staff

+34 935 811 525



Department of Biochemistry and Molecular Biology
Institut de Neurociències
Faculty  of Medicine (room M2-116)
Universitat Autònoma de Barcelona (UAB)
Bellaterra Campus 08193-Cerdanyola del Vallés


Thesis number in address

I started my scientific career as a Ph.D student in the laboratory of Prof. Isaac Blanco (Dpt. Biochemistry,Universitat  Autònoma de Barcelona; UAB) during 1986-1990. After my Ph.D, I move to the National Institute for Medical Research in London (1991-92) where I investigated long-term effects of glutamate receptor stimulation on glutamate release and presynaptic proteins under the supervision of Prof. A J. Patel and Prof. T.V.P Bliss. My second post-doctoral stage was in Montpellier (1993-94) to work in the laboratory of Prof. Joel Bockaertin a join research unit of the CNRS and INSERM. In Bockaert’s laboratory I worked in the regulation by glutamate receptors of neuronal NO synthesis. I came back as an assistant professor to the UAB in 1995 and in 1997 I was awarded a staff position in the Department of Biochemistry and Molecular Biology of the UAB as Associate Professor. I was able to run my own laboratory and research projects from 2000. Our laboratory is a founder group of the Spanish Center for Translational Research in Neurodegenerative Diseases (CIBERNED) since 2006.

During all these years at UAB, I’ve also been engaged with academic activities. Besides teaching at undergraduate and graduate levels, I will like to remark my appointment as Director of the Institut de Neurociències (INc) of the UAB from 2002 to 2008. I have been also awarded with the Full Professor accreditation from the Spanish Universities Council (ANECA) in 2010 and the Full Professor Advanced Research accreditation from AQU in 2011. At present I’m the Coordinator of the Neuroscience PhD program and member of the Board of Directors of the INc.

Dr. José Rodríguez Álvarez coordinates the Biomedical Research in Neurodegeneration and leads his own laboratory:
Laboratory members:
Judith Català Solsona- PhD student
Alfredo Jesús Miñano Molina- Postdoctoral scientist
Cristina Fàbregas- PhD student
Dolores Siedlecki- PhD student
Former members:
Dr. Guillem Sanchez Opazo
Dr. Wen wen Chen
Dr. Nahuai Badiola Benito
Dra. Bruna Barneda Zahonero
Dr. Xavi Xifró Collsamata
Dra. Cristina Malagelada Grau
Dra. Amaia Ochoa de Amárzaga
During the last years, the basic objective of our research team has been the study of the cellular and molecular mechanisms involved in the synaptic dysfunction and neuronal death as a straight approach for the understanding of neurodegeneration in diverse pathologies. At present, the laboratory is focused in the study of the mechanisms involved in early dysfunction of synaptic activity in Alzheimer’s disease.
During the last decade, the idea that the alteration of synaptic function in Alzheimer’s Disease (AD) occurs well before neurodegeneration is becoming widely accepted. Moreover, it has been suggested that the progressive accumulation of self-aggregates of Aβ as oligomers (oAβ) would mediate this synaptic dysfunction, leading to the initial cognitive deficits observed in mild cognitive impairment (MCI) and earlier AD stages.
In this context, we have recently observed that oAβ promotes the internalization of synaptic AMPA receptors (AMPAR) and also blocks the increase in synaptic AMPAR elicited by cLTP. Moreover, we have also reported a reduction of GluA1-AMPAR in APPSw,Ind mice in correlation with the early learning deficits previously observed in our laboratory. We postulate that prolonged interaction of oAβwith excitatory synapses could cause a deep effect on AMPARs levels through changes in the mechanisms that regulate AMPARs gene expression and trafficking. The identification of the molecular mechanisms involved in oAβ-mediated synaptic AMPAR functional alteration is a central issue of research in our laboratory.

See all José Rodríguez Alvarez publications at PubMed

Institut de Neurociències
Tel: 93 581 3861 / Fax: +34 93 581 3327

Facultat de Medicina. Edifici M-1
Avinguda de Can Domènech - Campus de la UAB · 08193
Bellaterra (Cerdanyola del Vallès) · Barcelona