Isabel Portell Cortés

Isabel  Portell Cortés

   

 

Isabel Portell Cortés

Academic Staff

Phone:
+34 935 813 220

Email:
isabel.portell@uab.cat

Adress:

Department of Psychobiology and Methodology of Health Science
Institut de Neurociències
Faculty  of Psychology (room B5-037)
Universitat Autònoma de Barcelona (UAB)
Bellaterra Campus 08193-Cerdanyola del Vallés

Area

Thesis number in address


I studied Psychology at the Universitat Autònoma de Barcelona (UAB), and began my scientific career in the field of Psychobiology in 1981, under the supervision of Ignacio Morgado. After defending my PhD thesis on the relationship between sleep and memory, in 1991 I got a tenure position in the UAB, and in 2019 I obtained a full professor position in the same University. My research has focused on studying the neurobiological mechanisms of learning and memory facilitation. I have conducted and coordinated research to study the facilitative effects of sleep, post-training epinephrine and physical exercise on learning and memory processes. Currently, my experimental research is focused on the capacity of physical exercise to reduce memory deficits in an animal model of traumatic brain injury, and on the underlying neurobiological mechanisms. We are also starting to study whether physical exercise, applied along with other interventions, can alleviate the cognitive deficiencies of patients with cranioencephalic trauma.
 In addition to my research activity, during these years I have been teaching psychobiology courses in the degree of Psychology, and in the master of Neuroscience of the UAB. I have been director of the Department of Psychobiology and Methodology of Health Sciences from 2008 to 2011, and since 2013 I hold the responsibility of the animal facilities of the Laboratory of Psychobiology.  I was also member of the Local Organizing Committee of the 35th Annual General Meeting of the European Brain and Behaviour Society (EBBS, Barcelona, 2003).

Dr. Isabel Portell is leading her own laboratory within the Memory Potentiation and Recovery in Normal and Brain damaged Rats research group:
 
 
Lab members:
Laura Amorós Aguilar
Margalida Coll Andreu (PI)
David Costa Miserachs
Meritxell Torras Garcia
 
Former lab members:
Silvia García Capdevila
Alejandra Jacotte Simancas
 
 
RESEARCH INTERESTS
 
 Our research interests are focused on the capacity of physical exercise to reduce cognitive deficits associated to brain injury and its underlying mechanisms of action.
 
 
STRATEGIC OBJECTIVES
 
The main objective of our group is to study the effects of exercise on cognitive processes. Currently, our research aims to reduce cognitive impairment caused by traumatic brain injury by means of physical exercise treatment, and to study the neurobiological mechanisms (neurogenesis, neuroprotection, neuroinflammation, etc.) that may mediate the effects of this treatment. In addition, we have started to study whether physical exercise, applied along with other interventions, can alleviate the cognitive deficiencies of patients with cranioencephalic trauma.
 
MAIN RESEARCH LINES
 
1) Establishment of the optimal conditions in which physical exercise is able to reduce memory deficits associated to traumatic brain injury.
 
2) To study the neuroprotective effects of physical exercise prior to traumatic brain injury, and its interaction with post-lesion physical exercise treatment.
 
3) To study sex differences in relation to the benefits of physical exercise on the cognitive deficits associated to traumatic brain injury.
 
4) Assessment of the benefits of physical exercise in traumatic brain injury patients.
 
 
CURRENT WORK
 
Our current work focuses on evaluating the effect of different intensities of forced physical exercise on memory deficits. The research group is also interested in studying whether physical exercise before a traumatic brain injury can reduce the cognitive deleterious effect of the lesion, and/or can improve the beneficial effects of a post-lesion physical exercise treatment. We have begun to study, also, whether physical exercise has similar benefits in female and male rats. Besides the behavioral study, we also analyze the cellular and molecular mechanisms underlying the cognitive benefits of exercise. 
Our research group is in contact with AVAN (Associació  Vallès Amics de la Neurologia) to start a study on the benefits of physical exercise in chronic patients with TBI.
 
  • Jacotte-Simancas, A.; Costa-Miserachs, D.; Coll-Andreu, M.; Torras-Garcia, M.; Borlongan, C.; Portell-Cortés, I. (2015). Effects of voluntary physical exercise, citicoline, and combined treatment on object recognition memory, neurogenesis and neuroprotection after traumatic brain injury in rats. Journal of Neurotrauma, 32 (739-751).
  • Amorós-Aguilar, L.; Portell-Cortés, I.; Costa-Miserachs, D.; Torras-Garcia, M.;  Coll-Andreu, M. (2015). Traumatic Brain Injury in Late Adolescent Rats: Effects on Adulthood Memory and Anxiety. Behavioral Neuroscience, 129 (2), 149-159
  • Jacotte-Simancas, A.; Costa-Miserachs, D.; Torras-Garcia, M., Coll-Andreu, M.; Portell-Cortés, I. (2013). Effects of voluntary physical exercise and post-training epinephrine on acquisition in a spatial task in the Barnes maze. Behavioural Brain Research, 247, 178-181.
  • Jurado-Berbel, P.; Costa-Miserachs, D.; Torras-Garcia, M.; Coll-Andreu, M.; Portell-Cortés, I. (2010). Standard object recognition memory and “what” and “where” components: Improvement by post-training epinephrine in highly habituated rats. Behavioural Brain Research, 207, 44-50.
  • García-Capdevila, S.; Portell-Cortés, I.; Torras-Garcia, M.; Coll-Andreu, M.; Costa-Miserachs, D. (2009). Effects of long-term voluntary exercise on learning and memory processes: dependency of the task and level of exercise. Behavioural Brain Research, 202, 162-170.

See all Isabel Portell-Cortés publications at PubMed.

Institut de Neurociències
Tel: 93 581 3861 / Fax: +34 93 581 3327

Facultat de Medicina. Edifici M-1
Avinguda de Can Domènech - Campus de la UAB · 08193
Bellaterra (Cerdanyola del Vallès) · Barcelona