An international collaboration published in Nature Communications, where Dr Emma Puighermanal-Puigvert is the first author, has shown that neurons expressing dopamine D2 receptors have different molecular features and functions, depending on their anatomical localization within the striatum.
A study coordinated by Dr. Assumpció Bosch, published in the journal Neurotherapeutics, proposes the use of gene therapy to treat megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare genetic disease that causes neurodegeneration.
For the first time we celebrated the INc Sant Jordi contest. Participants had to create a comic to disseminate neuroscientific content. It was difficult to choose the winners, as the level was very high, but finally, for their excellence, Melania González received the first prize, Georgina Palomés, the second, and Laura Sánchez, the third. Congrats!
NeuroHeal, a combo of repurposed drugs to restore peripheral nerve function, has been tested in damaged neonatal motoneurons of animal models, showing neuroprotective effect. This treatment was developed by a research team led by Dr. Caty Casas, who previously demonstrated the same effect in adult animal models.
A study coordinated by Dr. Alfredo J. Miñano, published in eNeuro journal, shows us the importance of the scaffold protein AKAP150 degradation in the regulation of AMPA-glutamate receptors associated with synaptic plasticity. This research will allow knowing better this protein and opening the possibility to use it as a therapeutic target in brain pathologies that present deregulation in synaptic AMPA receptors.
Mòdol-Caballero G, Herrando-Grabulosa M, García-Lareu B, Solanes N, Verdés S, Osta R, Francos-Quijorna I, López-Vales R, Calvo AC, Bosch A, Navarro X (2020).
Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice
Neurobiol Dis.,
https://www.ncbi.nlm.nih.gov/pubmed/32032731
Puig N, Montolio L, Camps-Renom P, Navarra L, Jiménez-Altayó F, Jiménez-Xarrié E, Sánchez-Quesada JL, Benitez S. (2020).
Electronegative LDL Promotes Inflammation and Triglyceride Accumulation in Macrophages.
Cells.,
https://www.ncbi.nlm.nih.gov/pubmed/32121518
Franco R, Rivas-Santisteban R, Casanovas M, Lillo A, Saura CA, Navarro G (2020).
Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease
Cells,
https://www.mdpi.com/2073-4409/9/5/1075
Romeo-Guitart D, Casas C. (2020).
NeuroHeal Treatment Alleviates Neuropathic Pain and Enhances Sensory Axon Regeneration.
Cells,
https://www.ncbi.nlm.nih.gov/pubmed/32230770