Once again, last week we hosted in our institute a number of young boys and girls participating in Campus ítaca, a summer campus organized by Fundació Autònoma Solidària. Following all the safety measures (wearing mask etc.), students from third grade of secondary school from diverse social environments learned about the nervous system through games and hands-on lab activities.
A study led by the Institut de Neurociències (INc-UAB) shows that APOE4, the principal genetic risk factor in developing the most common type of Alzheimer's disease, produces an alteration in the astrocytes' signaling mechanisms in male mice, which could be key for the development of this pathology. In females, however, this alteration occurs in different variants of APOE.
.jpg)
Due to the impossibility of ensuring participants’ safety in an event hosting more than 100 people indoors, we are forced to postpone the 8th edition of our conferences to the 5th, 6th and 7th of October 2021.
An international study by Dr. Jose Manuel López, in collaboration with the Emory University and Hospital Universitario La Paz, published in the PNAS journal, shows that patients suffering from Lesch-Nyhan, a rare neurological disease, present biochemical alterations in fibroblasts, urine and cerebrospinal fluid. Researchers have also discovered that these alterations had not been observed before because the high levels of folic acid usually used in cell cultures reverse them.
A study led by Dr. Jose Miguel Lizcano describes a new strategy to tackle cancer, based on inducing a potent stress in tumor causing cell destruction by autophagy. The mechanism has been revealed using the new antitumor drug ABTL0812, currently in clinical trial. Results has been validated using samples from oncologic patients, and published in Autophagy.
Romeo-Guitart D, Marcos-DeJuana C, Marmolejo-Martínez-Artesero S, Navarro X, Casas C. (2020).
Novel neuroprotective therapy with NeuroHeal by autophagy induction for damaged neonatal motoneurons
Theranostics,
https://www.thno.org/v10p5154.htm
Puighermanal E, Castell L, Esteve-Codina A, Melser S, Kaganovsky K, Zussy C, Boubaker-Vitre J, Gut M, Rialle S, Kellendonk C, Sanz E, Quintana A, Marsicano G, Martin M, Rubinstein M, Girault JA, Ding JB, Valjent E. (2020).
Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum.
Nat Commun.,
https://www.nature.com/articles/s41467-020-15716-9.pdf
Bartolomé, I., Llidó, A., Darbra, S., Pallarès, M (2020).
Early postnatal allopregnanolone levels alteration and adult behavioral disruption in rats: Implication for drug abuse
Neurobiology of Stress,
https://www.sciencedirect.com/science/article/pii/S2352289519300608
Raspopovic S, Cimolato A, Panarese A, Vallone F, Del Valle J, Micera S, Navarro X. (2020).
Neural signal recording and processing in somatic neuroprosthetic applications. A review.
J Neurosci Methods. ,
https://www.ncbi.nlm.nih.gov/pubmed/32114143