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Campus ítaca at INc-UAB

Campus ítaca at INc-UAB

Once again, last week we hosted in our institute a number of young boys and girls participating in Campus ítaca, a summer campus organized by Fundació Autònoma Solidària. Following all the safety measures (wearing mask etc.), students from third grade of secondary school from diverse social environments learned about the nervous system through games and hands-on lab activities.

Biochemical alterations revealed in patients with Lesch-Nyhan disease

Biochemical alterations revealed in patients with Lesch-Nyhan disease

An international study by Dr. Jose Manuel López, in collaboration with the Emory University and Hospital Universitario La Paz, published in the PNAS journal, shows that patients suffering from Lesch-Nyhan, a rare neurological disease, present biochemical alterations in fibroblasts, urine and cerebrospinal fluid. Researchers have also discovered that these alterations had not been observed before because the high levels of folic acid usually used in cell cultures reverse them.

New pathway to attack tumor cells identified

New pathway to attack tumor cells identified

A study led by Dr. Jose Miguel Lizcano describes a new strategy to tackle cancer, based on inducing a potent stress in tumor causing cell destruction by autophagy. The mechanism has been revealed using the new antitumor drug ABTL0812, currently in clinical trial. Results has been validated using samples from oncologic patients, and published in Autophagy.

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Publications

Romeo-Guitart D, Marcos-DeJuana C, Marmolejo-Martínez-Artesero S, Navarro X, Casas C. (2020).
Novel neuroprotective therapy with NeuroHeal by autophagy induction for damaged neonatal motoneurons
Theranostics,
https://www.thno.org/v10p5154.htm

Puighermanal E, Castell L, Esteve-Codina A, Melser S, Kaganovsky K, Zussy C, Boubaker-Vitre J, Gut M, Rialle S, Kellendonk C, Sanz E, Quintana A, Marsicano G, Martin M, Rubinstein M, Girault JA, Ding JB, Valjent E. (2020).
Functional and molecular heterogeneity of D2R neurons along dorsal ventral axis in the striatum.
Nat Commun.,
https://www.nature.com/articles/s41467-020-15716-9.pdf

Raspopovic S, Cimolato A, Panarese A, Vallone F, Del Valle J, Micera S, Navarro X. (2020).
Neural signal recording and processing in somatic neuroprosthetic applications. A review.
J Neurosci Methods. ,
https://www.ncbi.nlm.nih.gov/pubmed/32114143